3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- → HCID 67216944, compound

Participants

Reaction Steps

A solution of 4-(trifluoromethyl)nicotinic acid (1.50 g, 7.85 mmol) in EtOH (78 mL) was passed through an H-cube™ equipped with a ThalesNano CatCart® 10 wt % Pd/C catalyst cartridge at about 1.0 mL/min, at about 80° C., under about 1305 psi of hydrogen. After about 3 h, the solvent was removed under reduced pressure to afford cis-4-(trifluoromethyl)piperidine-3-carboxylic acid (1.55 g, 100% crude): LC/MS (Table 1, Method b) Rt=0.54 min; MS m/z: 198 (M+H)+.

Provenance & Evidence