Diisopropylethylamine → HCID 58558077, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-cyanophenylboronic acid (0.143 g, 0.974 mmol) in DCM (4 mL) was added copper (II) acetate monohydrate (0.013 g, 0.122 mmol) and 4 Å molecular sieves. The reaction mixture was purged 3 times with oxygen. A solution of (1S,3R,4S)-3-methyl-4-(6-tosyl-6H-pyrrolo[2,3-e][1,2,4]-triazolo[4,3-a]pyrazin-1-yl)cyclopentanamine (0.20 g, 0.48 mmol, Preparation #19.2) and DIEA (0.085 mL, 0.487 mmol) in MeCN (1 mL) was added and the reaction mixture was heated at about 45° C. for about 18 h. Additional copper (II) acetate monohydrate (0.013 g, 0.122 mmol) was added and the reaction mixture was stirred for about 4 h. The reaction mixture was filtered through a pad of Celite® and concd under reduced pressure. The crude material was purified by silica gel chromatography eluting with a gradient of 0-60% EtOAc in DCM to give 3-((1S,3R,4S)-3-methyl-4-(6-tosyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentylamino)benzonitrile (0.16 g, 48%) as a dark brown solid: LC/MS (Table 1, Method c) Rt=1.54 min; MS m/z: 512 (M+H)+.

Provenance & Evidence