Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine → HCID 89449684, compound

Participants

Reaction Steps

To a solution of N-benzyl-1-methoxy-N-((trimethylsilyl)methyl)methanamine (9.98 mL, 39.0 mmol), and (Z)-ethyl pent-2-enoate (5 g, 39.0 mmol, Preparation #RRR.1) in DCM (50 mL) was added TFA (0.030 mL, 0.390 mmol) at rt. After about 2 d, the reaction mixture was concd in vacuo to provide crude cis-ethyl 1-benzyl-4-ethylpyrrolidine-3-carboxylate (9.8 g, 96%) as an oil. LC/MS (Table 1, Method a) Rt=0.51 min; MS m/z: 262 (M+H)+.

Provenance & Evidence