Diisopropylethylamine → HCID 58558080, compound

Participants

Reaction Steps

A solution of 8-(piperidin-4-yl)-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine (0.100 g, 0.269 mmol, Preparation #DDDDD.1), 1H-pyrazole-1-carboximidamid, hydrochloride (0.118 g, 0.807 mmol) and DIEA (0.188 mL, 1.08 mmol) in DMF (2 mL) was stirred at rt for about 72 h. The reaction mixture was purified by RP-HPLC (Table 1, Method 1) to give 4-(3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)piperidine-1-carboximidamide (0.037 g, 33%) as a brown oil: LC/MS (Table 1, Method b) Rt=1.82 min; MS m/z: 414 (M+H)+.

Provenance & Evidence