Oxygen → N-((1R,3R)-3-(6-tosyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentyl)aniline

Participants

Reaction Conditions

Reaction Steps

A 100 mL round bottom flask was sequentially charged with phenylboronic acid (0.123 g, 1.01 mmol), diacetoxycopper monohydrate (0.010 g, 0.05 mmol), powdered 4 {acute over (Å)} molecular sieves (0.375 g) and DCM (4 mL). The reaction mixture was stirred for about 10 min then a suspension of (1R,3R)-3-(6-tosyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanamine (0.20 g, 0.50 mmol) in DCM (2 mL) and MeCN (2 mL) was added. The flask was fitted with an oxygen balloon. The flask was purged with oxygen and then heated at about 40° C. for about 18 h. Additional diacetoxycopper monohydrate (0.010 g, 0.05 mmol) was added and the reaction mixture was heated at about 45° C. under an atomosphere of oxygen for about 3 days. DCM (50 mL) was added and the reaction mixture was filtered through a pad of Celite® while washing with DCM (20 mL). The filtrate was concd under reduced pressure and the residue was purified using silica gel chromatography (20 g) eluting with a gradient of 30-80% EtOAc in DCM to give N-((1R,3R)-3-(6-tosyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentyl)aniline (0.106 g, 45%): LC/MS (Table 1, Method b) Rt=2.39 min; MS m/z: 473 (M+H)+.

Provenance & Evidence