Ethanamine, 2,2,2-trifluoro- → HCID 67216455, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,2,2-trifluoroethanamine (0.080 g, 0.804 mmol) in DMF (3 mL) was added CDI (0.150 g, 0.926 mmol). The resulting solution was stirred at about 65° C. for about 2 h. 1-((cis)-4-ethylpyrrolidin-3-yl)-6-tosyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine (0.250 g, 0.609 mmol) was added and the reaction continued stirring at about 65° C. for about 2 h. The reaction was cooled to about ambient temperature. The solvent was removed under reduced pressure. The crude material was purified by flash chromatography on silica gel eluting with a gradient of 0-10% MeOH in afford (cis)-3-ethyl-4-(6-tosyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide (0.306 g, 94%) as a brown residue: LC/MS (Table 1, Method a) Rt=2.19 min; MS m/z: 536 (M+H)+.

Provenance & Evidence