HCID 178420346, compound → HCID 178511502, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (cis)-N,N-dibenzyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)cyclohexanamine (1.0 g, 2.3 mmol) in EtOH (30 mL) was added Pd(OH)2 on carbon (0.64 g, 0.46 mmol) and the resulting mixture was shaken under hydrogen pressure of about 30 psi on a Parr shaker at about 50° C. for about 7 h. The catalyst was filtered off using a pad of Celite® and the filtrate was concd under reduced pressure. The material was purified by chiral chromatography (Table 2, method 34). The collected fractions were combined, concd under reduced pressure and chased with EtOH (20 mL). The resulting solid was dried in a heated vacuum oven at about 60° C. to yield (cis)-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)cyclohexanamine (0.353 g, 60%) as a white solid: LC/MS (Table 1, Method a) Rt=0.85 min; MS m/z 256 (M+H)+.

Provenance & Evidence