P-Anisidine → HCID 86627466, compound

Participants

Reaction Steps

This compound is prepared according to synthesis 25, from 150 mg (0.46 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 64 μL (0.55 mmol) of 4-methoxyaniline. After purification by chromatography on silica (eluent dichloromethane/methanol/acetonitrile 95/3/2) then trituration in diethyl ether, 21 mg (10%) of 8-(4-methoxy-phenylsulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

Provenance & Evidence