4-Fluoroaniline → HCID 86627469, compound

Participants

Reaction Steps

This compound is prepared according to synthesis 25, from 300 mg (0.92 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 112 μL (1.1 mmol) of 4-fluoro-aniline. After purification by chromatography on silica (eluent dichloromethane/methanol 95/5) then trituration in water then diethyl ether, 45 mg (12%) of 8-(4-fluorophenylsulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

Provenance & Evidence