tert-Butyl (4-aminophenyl)carbamate → HCID 86627477, compound

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Reaction Steps

This compound is prepared according to synthesis 25, from 150 mg (0.46 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 115 mg (0.55 mmol) of N-tert-butoxycarbonyl-para-phenylenediamine. After purification by chromatography on silica gel (chloroform/methanol/ammonia 90/25/4) then trituration in diethyl ether, 5 mg (3%) of 8-(4-aminophenylsulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

Provenance & Evidence