Benzenamine, 4-(4-morpholinyl)- → HCID 86627479, compound

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Reaction Steps

This compound is prepared according to synthesis 25, from 150 mg (0.46 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 98 mg (0.55 mmol) of 4-morpholin-4-yl-aniline. After purification by chromatography on silica (eluent dichloromethane/methanol 95/5) then trituration in methanol, 57 mg (25%) of 8-(4-morpholin-4-yl-phenylsulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a gray solid.

Provenance & Evidence