Triethylamine → HCID 86627492, compound

Participants

Reaction Conditions

Reaction Steps

82 μL (0.59 mmol) of triethylamine is added to 60 mg (0.20 mmol) of 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate hydrochloride (synthesis 64) suspended in anhydrous dimethylformamide (1 mL). The mixture is cooled to 0° C., then 42 mg (0.21 mmol) of 4-fluoro-benzenesulfonyl chloride is added. The solution is stirred for 1 h at 0° C. The solvent is evaporated and the raw product obtained is purified by recrystallization from methanol to give 32 mg (38%) of 8-(4-fluoro-benzenesulfonylamino)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a light brown solid.

Provenance & Evidence