N-Acetylsulfanilyl chloride → HCID 86627501, compound

HRID 1969976Notes

Reaction equation

HRID 1969976 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[C:6]3[NH:13][CH:14]=[CH:15][C:5]=3[C:4]=2[CH:3]=1.Cl.[CH2:17]([C:19]([OH:21])=[O:20])[CH3:18].[C:22]([NH:25][C:26]1[CH:31]=[CH:30][C:29]([S:32](Cl)(=[O:34])=[O:33])=[CH:28][CH:27]=1)(=[O:24])[CH3:23]>CO>[C:22]([NH:25][C:26]1[CH:27]=[CH:28][C:29]([S:32]([NH:1][C:2]2[CH:11]=[CH:10][C:9]3[NH:8][C:7](=[O:12])[C:6]4[NH:13][CH:14]=[CH:15][C:5]=4[C:4]=3[CH:3]=2)(=[O:34])=[O:33])=[CH:30][CH:31]=1)(=[O:24])[CH3:23].[CH2:17]([C:19]([O-:21])=[O:20])[CH3:18]

Participants

4

Reactant 2

HCID 8481N-Acetylsulfanilyl chlorideHCID 68937404HCID 68937404, compound

Product 1

HCID 86627501HCID 86627501, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound is prepared according to synthesis 43, from 60 mg (0.20 mmol) of 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate hydrochloride (synthesis 64) and 50 mg (0.21 mmol) of 4-acetylamino-benzenesulfonyl chloride. After trituration in hot methanol, 35 mg (38%) of 8-(4-acetylamino-benzenesulfonylamino)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of an orange-brown solid.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-1ced3f229d4f44849f6950ea485e1133
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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