5-Chlorothiophene-2-sulfonyl chloride → HCID 86627506, compound

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Reaction Steps

This compound is prepared according to synthesis 45, from 60 mg (0.20 mmol) of 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate hydrochloride (synthesis 64) and 29 μL (0.21 mmol) of 5-chloro-thiophene-2-sulfonyl chloride. After recrystallization from methanol and trituration in hot methanol, 4 mg (3%) of 8-(5-chloro-thiophene-2-sulfonylamino)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

Provenance & Evidence