Methanesulfonyl chloride → HCID 86627507, compound

Participants

Reaction Steps

This compound is prepared according to synthesis 58, from 130 mg of 8-methylamino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate hydrochloride (synthesis 63) contaminated with 30% of 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate to which 33 μL (0.42 mmol) of methanesulfonyl chloride is added. After purification by chromatography on silica (eluent dichloromethane/methanol/acetonitrile 94/3/3), 32 mg (31%) of 8-(methanesulfonyl-methyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

Provenance & Evidence