HCID 86627510, compound → HCID 86627509, compound

Participants

Reaction Steps

134 mg (2.4 mmol) of iron is added to 72 mg (0.24 mmol) of 8-nitro-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate (synthesis 66) dissolved in 4 mL of acetic acid. The mixture is refluxed for 1 h. The solution is filtered while hot and the solid is rinsed with a minimum of hot acetic acid. The filtrate is evaporated, then the residue (mixture of 8-acetylamino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate and 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate 85/15) is purified by preparative LCMS to give 4 mg (5%) of 8-acetylamino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a gray solid.

Provenance & Evidence