Acetic Acid → HCID 86627511, compound

Participants

Reaction Steps

33 μL (0.41 mmol) of a 37% aqueous solution of formaldehyde, 20 μL (0.35 mmol) of acetic acid and 26 mg (0.41 mmol) of sodium cyanoborohydride are added to 100 mg (0.37 mmol) of 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate (synthesis 64) suspended in 1.2 ml of ethanol. The mixture is stirred for 6 hours at room temperature then 33 μL (0.41 mmol) of a 37% aqueous solution of formaldehyde, 20 μL (0.35 mmol) of acetic acid and 7 mg (0.11 mmol) of sodium cyanoborohydride are added again. The reaction mixture is stirred overnight at room temperature. The solvents are evaporated and the residue obtained is purified by preparative LCMS to give 5 mg (5%) of 8-dimethylamino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a white solid.

Provenance & Evidence