Formic Acid → HCID 86627512, compound

Participants

Reaction Conditions

Reaction Steps

74 μL (1.95 mmol) of formic acid is added slowly to 153 μL (1.63 mmol) of acetic anhydride cooled on an ice bath, then the reaction mixture is stirred for 2 hours at 60° C. The mixture is cooled to room temperature then added to a solution of 500 mg (1.63 mmol) of 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate hydrochloride (synthesis 64) dissolved in 5 mL of anhydrous dimethylformamide and 460 μL (3.25 mmol) of triethylamine. The reaction mixture is stirred for 2 hours at 60° C. The solvent is evaporated and the residue is triturated in hot methanol to give 359 mg (74%) of 8-formylamino-4-oxo-4,5-dihydro-3H -pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a pale pink solid.

Provenance & Evidence