反应详情

This compound is prepared according to synthesis 25, from 326 mg (1 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 236 mg (1 mmol) of 4-amino-1-tert-butoxycarbonyl piperidine hydrochloride and 700 μL (5 mmol) of triethylamine. After purification by chromatography on silica (eluent chloroform/methanol/ammonia 65/25/4) then trituration in methanol, 16 mg (4%) of 4-oxo-8-(piperidin-4-ylsulfamoyl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

1. customThis compound is prepared
2. customAfter purification by chromatography on silica (eluent chloroform/methanol/ammonia 65/25/4)