Triethylamine → HCID 86627519, Verbindung

HRID 1970003Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970003
Cl[S:2]([C:5]1[CH:14]=[CH:13][C:12]2[NH:11][C:10](=[O:15])[C:9]3[NH:16][CH:17]=[C:18]([C:19]([OH:21])=[O:20])[C:8]=3[C:7]=2[CH:6]=1)(=[O:4])=[O:3].Cl.[NH2:23][CH:24]1[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]1.C(N(CC)CC)C>>[O:15]=[C:10]1[C:9]2[NH:16][CH:17]=[CH:18][C:8]=2[C:7]2[CH:6]=[C:5]([S:2](=[O:3])(=[O:4])[NH:23][CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[CH:14]=[CH:13][C:12]=2[NH:11]1.[CH2:18]([C:19]([O-:21])=[O:20])[CH3:17]

Komponenten

4

Edukt 3

HCID 8471TriethylamineHCID 2756033tert-Butyl 4-aminopiperidine-1-carboxylate--hydrogen chloride (1/1)HCID 45121068HCID 45121068, Verbindung

Produkt 1

HCID 86627519HCID 86627519, VerbindungAusbeute 7,6 %

Versuchsvorschrift

This compound is prepared according to synthesis 25, from 326 mg (1 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 236 mg (1 mmol) of 4-amino-1-tert-butoxycarbonyl piperidine hydrochloride and 700 μL (5 mmol) of triethylamine. After purification by chromatography on silica (eluent chloroform/methanol/ammonia 65/25/4) then trituration in methanol, 16 mg (4%) of 4-oxo-8-(piperidin-4-ylsulfamoyl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

Aufarbeitung

  1. customThis compound is prepared
  2. customAfter purification by chromatography on silica (eluent chloroform/methanol/ammonia 65/25/4)

Quellen und Nachweise

ORD-Eintrag
ord-dae05cc5b389471bbc72dbd7a0506abb
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426437B2

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