Triethylamine → HCID 86627520, compound

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Reaction Steps

This compound is prepared according to synthesis 25, from 200 mg (0.6 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2), 100 mg (0.8 mmol) of 3-aminoquinuclidine (in free form) and 170 μL (1.22 mmol) of triethylamine. After purification by chromatography on silica (eluent chloroform/methanol/ammonia 85/13/2), 11 mg (4%) of 8-(1-azabicyclo[2.2.2]oct-3-ylsulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a brown solid.

Provenance & Evidence