Potassium Carbonate → HCID 57576034, compound

Participants

Reaction Steps

9 mg (0.04 mmol) of 3-bromo-N-tert-butoxycarbonyl-propylamine and 8 mg (0.06 mmol) of potassium carbonate are added to a solution of 21 mg (0.05 mmol) of 8-[(4-fluorophenyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid dissolved in 0.5 mL of dimethylformamide. The reaction mixture is stirred for 18 hours at room temperature then the solvents are evaporated. The residue is purified by chromatography on silica (eluent cyclohexane/ethyl acetate 2/8) then triturated in diethyl ether to give 6 mg (21%) of 3-tert-butoxycarbonylamino-propyl 8-[(4-fluorophenyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylate in the form of a white solid.

Provenance & Evidence