Triethylamine → HCID 68933778, compound

Participants

Reaction Steps

8-[(4-tert-Butoxycarbonyl-cyclohexyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid is prepared according to synthesis 178, from 653 mg (2 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid, 334 mL (2.4 mmol) of triethylamine and 557 mg (2.6 mmol) of 4-methylamino-1-tert-butoxycarbonyl-piperidine to give, after purification by precipitation and trituration in water, 770 mg (76%) of 8-[(4-tert-butoxycarbonyl-cyclohexyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a beige solid.

Provenance & Evidence