Water → tert-Butyl 4-(methylamino)piperidine-1-carboxylate

Participants

Reaction Steps

3.8 mL (13 mmol) of titanium isopropoxide and 2 g (10 mmol) of 1-tert-butoxycarbonyl-piperidin-4-one are added to 3.7 mL (30 mmol) of a 33% solution of methylamine in ethanol. The solution is stirred for 5 hours at room temperature then 378 mg (10 mmol) of sodium borohydride is added. Stirring is continued for a further 2 hours then 2 mL of water is added. The reaction mixture is filtered then the solvents are evaporated to give 1.18 g (55%) of 4-methylamino-1-tert-butoxycarbonyl-piperidine in the form of an oil.

Provenance & Evidence