HCID 68933671, compound → HCID 86627528, compound

Participants

Reaction Steps

4 mg of activated Pd 10% on charcoal is added to a solution of 75 mg (0.14 mmol) of 8-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylsulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate dissolved in 15 mL of ethanol. The solution is stirred under a hydrogen atmosphere at room temperature for 18 hours then filtered on celite. The filtrate is evaporated and the residue is purified by chromatography on silica (eluent dichloromethane/methanol/ammonia 200/25/4) to give 20 mg (32%) of 8-(8-aza-bicyclo[3.2.1]oct-3-ylsulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a brown solid.

Provenance & Evidence