Hydrochloric Acid → HCID 68938445, compound

Participants

Reaction Steps

2 mL (4 mmol) of a 2M solution of hydrochloric acid in diethyl ether is added to a solution of 50 mg (0.1 mmol) of 8-{[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-sulfamoyl}-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate dissolved in 5 mL of anhydrous tetrahydrofuran. The solution is stirred at room temperature for 3 days then the solid that forms is filtered, and triturated in diisopropyl ether to give 26 mg (60%) of 8-[methyl-(2-methylamino-ethyl)-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate hydrochloride in the form of a white solid.

Provenance & Evidence