Triethylamine → HCID 178524788, compound

Participants

Reaction Steps

8-[Cyclopropyl-(1H-imidazol-4-ylmethyl)-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid is prepared according to synthesis 178, from 284 mg (0.87 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid, 605 μL (4.35 mmol) of triethylamine and 309 mg (1.3 mmol) of cyclopropyl-(1-tert-butoxycarbonyl-1H-imidazol-4-ylmethyl)-amine to give, after purification by precipitation and trituration in water, 350 mg (76%) of 8-[cyclopropyl-(1H-imidazol-4-ylmethyl)-sulfamoyl]-4-oxo-4,5-dihydro-3H -pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a beige solid.

Provenance & Evidence