Trifluoroacetic acid → HCID 86627537, compound

Participants

Reaction Steps

Trifluoroacetic acid (1 mL) is added slowly to a solution of 95 mg (0.2 mmol) of 8-(tert-butoxycarbonylmethyl-methyl-sulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate dissolved in 9 mL of dichloroethane. The solution is stirred at room temperature for 5 hours then the solvents are evaporated. The residue is taken up and triturated in acetonitrile then in diisopropyl ether to give 76 mg (90%) of 8-(carboxymethyl-methyl-sulfamoyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate in the form of a white solid.

Provenance & Evidence