Acetic Acid → HCID 86627539, compound

Participants

Reaction Conditions

Reaction Steps

In a sealed tube, 601 mg (1.8 mmol) of 7-fluoro-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate cocrystallized with one equivalent of acetic acid is dissolved in 2.4 mL (36 mmol) of chlorosulfonic acid. The reaction mixture is placed on an oil bath heated beforehand to 85° C. for 2 hours, cooled on an ice bath then poured slowly onto crushed ice. The solid is filtered, rinsed with water, diisopropyl ether and pentane then dried under vacuum to give 580 mg (93%) of 8-chlorosulfonyl-7-fluoro-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a brown solid.

Provenance & Evidence