Chlorosulfonic acid → HCID 86627543, compound

Participants

Reaction Conditions

Reaction Steps

In a sealed tube, 1.16 g (4 mmol) of 7-chloro-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is dissolved in 5.3 mL (80 mmol) of chlorosulfonic acid. The reaction mixture is placed on an oil bath heated beforehand to 90° C. for 6 hours, cooled on an ice bath then poured slowly onto crushed ice. The solid is filtered, rinsed with water, diisopropyl ether and pentane then dried under vacuum to give 1.3 g (90%) of 7-chloro-8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a brown solid.

Provenance & Evidence