Trisodium Phosphate → HCID 86627545, compound

Participants

Reaction Conditions

Reaction Steps

180 mg (0.55 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid is added to a solution of 139 mg (1.1 mmol) of sodium sulfite and 78 mg (0.55 mmol) of dibasic sodium phosphate dissolved in 2.5 mL of water. The solution is heated at 60° C. for 20 hours then a solution of 132 mg (0.55) of 2,6-dichlorobenzyl bromide in 2.5 mL of dimethylformamide is added. Stirring is continued at 60° C. for 4 hours then the solution is filtered. The solid is triturated in hot methanol then filtered again to give 88 mg (35%) of 8-(2,6-dichlorophenylmethanesulfonyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a white solid.

Provenance & Evidence