Water → HCID 86627546, compound

Participants

Reaction Steps

A solution of 410 mg (0.66 mmol) of Oxone in 2 mL of water is added to a solution of 49 mg (0.13 mmol) of 8-cyclohexylsulfanyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in methanol (5 mL) and acetonitrile (1 mL). The solution is stirred at room temperature for 24 hours. The solvents are evaporated then the residue is taken up in water. The product is extracted with ethyl acetate and the organic phases are dried over magnesium sulfate, filtered and evaporated. The residue is triturated in diethyl ether to give 40 mg (74%) of 8-cyclohexanesulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a white solid.

Provenance & Evidence