Potassium Carbonate → HCID 86627548, compound

Participants

Reaction Conditions

Reaction Steps

41 mg (0.24 mmol) of metachloroperbenzoic acid is added at 0° C. to a solution of 90 mg (0.24 mmol) of 8-benzylsulfanyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate suspended in dichloromethane (8 mL) and dioxan (8 mL). The reaction mixture is stirred for 6 hours at 0-5° C. then an aqueous solution of potassium carbonate is added and the product is extracted with ethyl acetate. The organic phase is washed with an aqueous solution of sodium chloride, dried over magnesium sulfate, filtered and evaporated. The residue is purified by preparative LCMS to give 40 mg (42%) of 4-oxo-8-phenylmethanesulfinyl-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a white solid.

Provenance & Evidence