Trifluoroacetic acid → HCID 86627570, compound

Participants

Reaction Steps

0.5 mL of trifluoroacetic acid is added to a solution of 100 mg (0.22 mmol) of 8-(2-tert-butoxycarbonylaminophenyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate dissolved in 2 mL of dichloroethane. The solution is stirred at room temperature for 30 minutes then the solvents are evaporated. The residue is triturated with diisopropyl ether then the solid is filtered and washed with dichloromethane. It is taken up in 2 mL of dichloromethane then triethylamine is added to release the amine. Water is added and the compound is extracted with dichloromethane. The organic phases are dried over magnesium sulfate, filtered and evaporated. The solid is triturated with water to give 35 mg (45%) of 8-(2-aminophenyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a white solid.

Provenance & Evidence