Trifluoroacetic acid → HCID 86627576, compound

Participants

Reaction Steps

1 mL of trifluoroacetic acid is added to a solution of 70 mg (0.15 mmol) 8-(1-tert-butoxycarbonyl-1H-indol-5-yl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate dissolved in 4 mL of dichloroethane. The solution is stirred for 2 hours at room temperature then the precipitate that forms is filtered and washed with diethyl ether to give 26 mg (45%) of 8-(1H -indol-5-yl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a brown solid.

Provenance & Evidence