Rhodanine → 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-thioxo-thiazolidin-4-one

HRID 1970117Notes

Reaction equation

HRID 1970117 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=O)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.N1C2C(=CC(C=O)=CC=2)C=N1.[S:35]=[C:36]1[NH:40][C:39](=[O:41])[CH2:38][S:37]1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:38]4[S:37][C:36](=[S:35])[NH:40][C:39]4=[O:41])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:21])([F:23])[F:22])[CH:3]=1

Participants

4

Reactant 3

HCID 1201546RhodanineHCID 212506441H-Indazole-5-carboxaldehydeHCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 866565215-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-thioxo-thiazolidin-4-one

Procedure

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-thioxo-thiazolidin-4-one was prepared from 1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde was prepared from 1H-indazole-5-carbaldehyde and 2-thioxo-thiazolidin-4-one following General Procedure B.

Sources & evidence

ORD record
ord-494a2a672c52469e9c58a1b4a7cfa77d
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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