3-(Methylamino)propane-1,2-diol → HCID 67345657, compound

HRID 1970121Notes

Reaction equation

HRID 1970121 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SCC)[NH:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:28]([F:31])([F:30])[F:29])[CH:3]=1.[CH3:32][NH:33][CH2:34][CH:35]([OH:38])[CH2:36][OH:37]>>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:33]([CH2:34][CH:35]([OH:38])[CH2:36][OH:37])[CH3:32])=[N:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:28]([F:29])([F:30])[F:31])[CH:3]=1

Participants

3

Reactant 2

HCID 27341223-(Methylamino)propane-1,2-diolHCID 866565235-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazolidin-4-one

Product 1

HCID 67345657HCID 67345657, compound

Procedure

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(2,3-dihydroxy-propyl)-methyl-amino]-thiazol-4-one was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazolidin-4-one and 3-Methylamino-propane-1,2-diol following General Procedure C.

Sources & evidence

ORD record
ord-245bf130ec9f4eb79d8097ae13b05b2d
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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