Sodium borohydride → HCID 67240522, compound

HRID 1970124Notes

Reaction equation

HRID 1970124 reaction equation
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[C:5]([C:11]([F:14])([F:13])[F:12])[CH:4]=1.[BH4-].[Na+]>CO>[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[C:5]([C:11]([F:12])([F:13])[F:14])[CH:4]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 81647511HCID 81647511, compound

Product 1

HCID 67240522HCID 67240522, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Methylsulfanyl-2-trifluoromethyl-benzaldehyde (4.87 mmol) was dissolved in mL of MeOH and the resulting solution was treated with NaBH4 (221.1 mg, 5.84 mmol). The reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated and the residue was partitioned between CH2Cl2 and 1N HCl solution. The combined extracts were washed with brine, dried over Na2SO4. A small portion of extracts was evaporated to afford the desired product.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was partitioned between CH2Cl2 and 1N HCl solution
  3. washThe combined extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. customA small portion of extracts was evaporated

Sources & evidence

ORD record
ord-5f30dccde8eb43b3ae6fa2eae30fef58
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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