3-(Methylamino)propane-1,2-diol → HCID 67345819, compound

HRID 1970128Notes

Reaction equation

HRID 1970128 reaction equation
[CH3:1][S:2]([C:5]1[CH:29]=[CH:28][C:8]([CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([CH:19]=[C:20]4[S:24][C:23](SC)=[N:22][C:21]4=[O:27])=[CH:16][CH:17]=3)[CH:12]=[N:11]2)=[C:7]([C:30]([F:33])([F:32])[F:31])[CH:6]=1)(=[O:4])=[O:3].[CH3:34][NH:35][CH2:36][CH:37]([OH:40])[CH2:38][OH:39]>>[OH:40][CH:37]([CH2:38][OH:39])[CH2:36][N:35]([CH3:34])[C:23]1[S:24][C:20](=[CH:19][C:15]2[CH:14]=[C:13]3[C:18](=[CH:17][CH:16]=2)[N:10]([CH2:9][C:8]2[CH:28]=[CH:29][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][C:7]=2[C:30]([F:32])([F:31])[F:33])[N:11]=[CH:12]3)[C:21](=[O:27])[N:22]=1

Participants

3

Reactant 2

HCID 27341223-(Methylamino)propane-1,2-diolHCID 67239959HCID 67239959, compound

Product 1

HCID 67345819HCID 67345819, compound

Procedure

2-[(2,3-Dihydroxy-propyl)-methyl-amino]-5-[1-(4-methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one was prepared from 5-[1-(4-methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and 3-Methylamino-propane-1,2-diol following General Procedure C.

Sources & evidence

ORD record
ord-21ab7cbac6254107bc9501956287e6e2
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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