tert-Butyl 4-(methylamino)piperidine-1-carboxylate → HCID 86656526, compound

HRID 1970139Notes

Reaction equation

HRID 1970139 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19](SC)=[N:18][C:17]3=[O:23])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[CH3:34][NH:35][CH:36]1[CH2:41][CH2:40][N:39]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:38][CH2:37]1>>[C:45]([O:44][C:42]([N:39]1[CH2:38][CH2:37][CH:36]([N:35]([C:19]2[S:20][C:16](=[CH:15][C:11]3[CH:10]=[C:9]4[C:14](=[CH:13][CH:12]=3)[N:6]([CH2:5][C:4]3[CH:24]=[CH:25][C:26]([C:28]([F:31])([F:30])[F:29])=[CH:27][C:3]=3[C:2]([F:1])([F:32])[F:33])[N:7]=[CH:8]4)[C:17](=[O:23])[N:18]=2)[CH3:34])[CH2:41][CH2:40]1)=[O:43])([CH3:48])([CH3:47])[CH3:46]

Participants

3

Reactant 2

HCID 15380702tert-Butyl 4-(methylamino)piperidine-1-carboxylateHCID 866545435-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]2-methylsulfanyl-thiazol-4-one

Product 1

HCID 86656526HCID 86656526, compound

Procedure

4-({5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and tert-butyl 4-(methylamino)piperidine-1-carboxylate following General Procedure B.

Sources & evidence

ORD record
ord-ee9247eaa1394e3d95728b7dacea0ac3
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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