(+)-Synephrine → HCID 67348996, compound

HRID 1970150Notes

Reaction equation

HRID 1970150 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SC)[NH:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[OH:31][C@H:32]([C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=1)[CH2:33][NH:34][CH3:35]>>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:34]([CH2:33][C@H:32]([OH:31])[C:36]5[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=5)[CH3:35])=[N:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1

Participants

3

Reactant 2

HCID 854067(+)-SynephrineHCID 866565225-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one

Product 1

HCID 67348996HCID 67348996, compound

Procedure

(R)-5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-{[2-hydroxy-2-(4-hydroxy-phenyl)-ethyl]-methyl-amino}-thiazol-4-one was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one and (R)-4-(1-Hydroxy-2-methylamino-ethyl)-phenol following General Procedure B.

Sources & evidence

ORD record
ord-dd7d3de0ccf4445784e5cf55b4b18648
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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