{1-[(Methylamino)methyl]cyclopropyl}methanol → HCID 67349297, compound

HRID 1970154Notes

Reaction equation

HRID 1970154 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SC)[NH:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[CH3:31][NH:32][CH2:33][C:34]1([CH2:37][OH:38])[CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:32]([CH2:33][C:34]5([CH2:37][OH:38])[CH2:36][CH2:35]5)[CH3:31])=[N:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:28])([F:29])[F:30])[CH:3]=1

Participants

3

Reactant 2

HCID 25220857{1-[(Methylamino)methyl]cyclopropyl}methanolHCID 866565225-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one

Product 1

HCID 67349297HCID 67349297, compound

Procedure

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(1-hydroxymethyl-cyclopropylmethyl)-methyl-amino]-thiazol-4-one was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one and (1-methylaminomethyl-cyclopropyl)-methanol following General Procedure B.

Sources & evidence

ORD record
ord-bcc417b682e441449f2936f7a2a4c9b9
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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