1-Piperidinecarboxylic acid, 4-(methylamino)-, ethyl ester → HCID 67347114, compound

HRID 1970155Notes

Reaction equation

HRID 1970155 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SC)[NH:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[CH2:31]([O:33][C:34]([N:36]1[CH2:41][CH2:40][CH:39]([NH:42][CH3:43])[CH2:38][CH2:37]1)=[O:35])[CH3:32]>>[CH2:31]([O:33][C:34]([N:36]1[CH2:37][CH2:38][CH:39]([N:42]([C:20]2[S:21][C:17](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:25]=[CH:26][C:2]([Cl:1])=[CH:3][C:4]=3[C:27]([F:28])([F:30])[F:29])[N:8]=[CH:9]4)[C:18](=[O:24])[N:19]=2)[CH3:43])[CH2:40][CH2:41]1)=[O:35])[CH3:32]

Participants

3

Reactant 2

HCID 110631401-Piperidinecarboxylic acid, 4-(methylamino)-, ethyl esterHCID 866565225-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one

Product 1

HCID 67347114HCID 67347114, compound

Procedure

4-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-piperidine-1-carboxylic acid ethyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one and 4-methylamino-piperidine-1-carboxylic acid ethyl ester following General Procedure B.

Sources & evidence

ORD record
ord-048e68b8b19e4f7bad71447bb528e88b
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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