2-(Allyl-methyl-amino)-thiazol-4-one → 2-(Allyl-methyl-amino)-5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one

HRID 1970158Notes

Reaction equation

HRID 1970158 reaction equation
[CH2:1]([N:4]([CH3:11])[C:5]1[S:6][CH2:7][C:8](=[O:10])[N:9]=1)[CH:2]=[CH2:3].[Cl:12][C:13]1[CH:30]=[CH:29][C:16]([CH2:17][N:18]2[C:26]3[C:21](=[CH:22][C:23]([CH:27]=O)=[CH:24][CH:25]=3)[CH:20]=[N:19]2)=[C:15]([C:31]([F:34])([F:33])[F:32])[CH:14]=1>>[CH2:1]([N:4]([CH3:11])[C:5]1[S:6][C:7](=[CH:27][C:23]2[CH:22]=[C:21]3[C:26](=[CH:25][CH:24]=2)[N:18]([CH2:17][C:16]2[CH:29]=[CH:30][C:13]([Cl:12])=[CH:14][C:15]=2[C:31]([F:34])([F:32])[F:33])[N:19]=[CH:20]3)[C:8](=[O:10])[N:9]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 145483022-(Allyl-methyl-amino)-thiazol-4-oneHCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 673470712-(Allyl-methyl-amino)-5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one

Procedure

2-(Allyl-methyl-amino)-5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one was prepared from 2-(allyl-methyl-amino)-thiazol-4-one and 1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde following General Procedure E.

Sources & evidence

ORD record
ord-59b2ae984aa74b0e82447c5c4f7da692
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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