HCID 20705157, compound → HCID 86656529, compound

HRID 1970162Notes

Reaction equation

HRID 1970162 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[CH:25][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19](SCC)=[N:18][C:17]3=[O:24])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[CH3:35][O:36][CH2:37][CH:38]1[N:42]([CH3:43])[CH2:41][CH:40]([NH:44][CH3:45])[CH2:39]1>>[F:1][C:2]([F:34])([F:33])[C:3]1[CH:28]=[C:27]([C:29]([F:31])([F:32])[F:30])[CH:26]=[CH:25][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19]([N:44]([CH:40]4[CH2:39][CH:38]([CH2:37][O:36][CH3:35])[N:42]([CH3:43])[CH2:41]4)[CH3:45])=[N:18][C:17]3=[O:24])=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 20705157HCID 20705157, compoundHCID 866545405-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one

Product 1

HCID 86656529HCID 86656529, compound

Procedure

5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(5-methoxymethyl-1-methyl-pyrrolidin-3-yl)-methyl-amino]-thiazol-4-one was prepared from 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and (5-Methoxymethyl-1-methyl-pyrrolidin-3-yl)-methyl-amine following General Procedure C.

Sources & evidence

ORD record
ord-2452461549a34f8e8e4de49ec2385c81
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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