HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1970163Generated: October 27, 2026
Methylamine → tert-butyl N-(2-hydroxy-3-(methylamino)propyl)carbamate
https://huagongshe.com/reaction/1970163
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | tert-Butyl N-(2-oxiranylmethyl)carbamate | HCID 11062891 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-butyl N-(2-hydroxy-3-(methylamino)propyl)carbamate | HCID 58981742 | — |
Reaction Steps
A solution of Oxiranylmethyl-carbamic acid tert-butyl ester (0.64 g, 3.7 mmol) in Ethanol (6 mL) was treated at room temperature with a 2.0M solution of methylamine in THF (5 mL, 10 mmol). The reaction mixture was stirred for 5 hours at 40° C. The solvent was evaporated in vacuo to yield a gum which was used directly into the next step (0.75 g, 98%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426604B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-21d33b3ba71b4718b4d2e64e1d0f5f48 |
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| Source note | uspto-grants-2013_04 |
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