tert-Butyl 3-(methylamino)azetidine-1-carboxylate → 3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-azetidine-1-carboxylic acid tert-butyl ester

HRID 1970167Notes

Reaction equation

HRID 1970167 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SCCC)[NH:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[C:33]([O:37][C:38]([N:40]1[CH2:43][CH:42]([NH:44][CH3:45])[CH2:41]1)=[O:39])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38]([N:40]1[CH2:41][CH:42]([N:44]([C:20]2[S:21][C:17](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:27]=[CH:28][C:2]([Cl:1])=[CH:3][C:4]=3[C:29]([F:32])([F:30])[F:31])[N:8]=[CH:9]4)[C:18](=[O:26])[N:19]=2)[CH3:45])[CH2:43]1)=[O:39])([CH3:36])([CH3:35])[CH3:34]

Participants

3

Reactant 2

HCID 23153172tert-Butyl 3-(methylamino)azetidine-1-carboxylateHCID 866565305-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one

Product 1

HCID 673492163-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-azetidine-1-carboxylic acid tert-butyl ester

Procedure

3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-azetidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one and 3-Methylamino-azetidine-1-carboxylic acid tert-butyl ester following General Procedure B.

Sources & evidence

ORD record
ord-f0c450a41b7c4bf999f57407a5b794ad
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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