HRID1970167

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23153172

tert-Butyl 3-(methylamino)azetidine-1-carboxylate

C9H18N2O2

结构：CCCSC1NC(=O)C(=Cc2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)S1

HCID86656530

未命名化合物

PRODUCTS

生成物

结构：CN(C1=NC(=O)C(=Cc2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)S1)C1CN(C(=O)OC(C)(C)C)C1

HCID67349216

未命名化合物

PROCEDURE

实验过程

3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-azetidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one and 3-Methylamino-azetidine-1-carboxylic acid tert-butyl ester following General Procedure B.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f0c450a41b7c4bf999f57407a5b794ad
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08426604B2
来源说明: uspto-grants-2013_04

反应 SMILES

[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SCCC)[NH:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[C:33]([O:37][C:38]([N:40]1[CH2:43][CH:42]([NH:44][CH3:45])[CH2:41]1)=[O:39])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38]([N:40]1[CH2:41][CH:42]([N:44]([C:20]2[S:21][C:17](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:27]=[CH:28][C:2]([Cl:1])=[CH:3][C:4]=3[C:29]([F:32])([F:30])[F:31])[N:8]=[CH:9]4)[C:18](=[O:26])[N:19]=2)[CH3:45])[CH2:43]1)=[O:39])([CH3:36])([CH3:35])[CH3:34]