tert-butyl N-[2-hydroxy-3-(methylamino)propyl]-N-methylcarbamate → [3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-2-hydroxy-propyl]-methyl-carbamic acid tert-butyl ester

HRID 1970168Notes

Reaction equation

HRID 1970168 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SCCC)[NH:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[C:33]([O:37][C:38](=[O:47])[N:39]([CH2:41][CH:42]([OH:46])[CH2:43][NH:44][CH3:45])[CH3:40])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38](=[O:47])[N:39]([CH2:41][CH:42]([OH:46])[CH2:43][N:44]([C:20]1[S:21][C:17](=[CH:16][C:12]2[CH:11]=[C:10]3[C:15](=[CH:14][CH:13]=2)[N:7]([CH2:6][C:5]2[CH:27]=[CH:28][C:2]([Cl:1])=[CH:3][C:4]=2[C:29]([F:30])([F:31])[F:32])[N:8]=[CH:9]3)[C:18](=[O:26])[N:19]=1)[CH3:45])[CH3:40])([CH3:36])([CH3:34])[CH3:35]

Participants

3

Reactant 2

HCID 84683868tert-butyl N-[2-hydroxy-3-(methylamino)propyl]-N-methylcarbamateHCID 866565305-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one

Product 1

HCID 67347493[3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-2-hydroxy-propyl]-methyl-carbamic acid tert-butyl ester

Procedure

[3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-2-hydroxy-propyl]-methyl-carbamic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one and (2-Hydroxy-3-methylamino-propyl)-methyl-carbamic acid tert-butyl ester following General Procedure B.

Sources & evidence

ORD record
ord-c0681aeb60324205a19b9afbe20ff2c6
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

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