Potassium Carbonate → HCID 76021232, compound

Participants

Reaction Steps

To a solution of 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(methyl-piperidin-4-yl-amino)-thiazol-4-one (Example 17) (80 mg, 0.14 mmol) in DMF (2 mL) was added potassium carbonate (39 mg, 0.28 mmol) followed by 2-Bromo-acetamide (23 mg, 0.17 mmol). The reaction mixture was stirred at room temperature for 4 hours and partitioned between water and ethyl acetate. The ethyl acetate layer was washed with brine, dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude solid. The crude solid was purified via flash chromatography (5% methanol in dichloromethane) to yield the title compound (61 mg, 69%).

Provenance & Evidence