Potassium Carbonate → HCID 86656533, compound

Participants

Reaction Steps

To a solution of 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(methyl-piperidin-4-yl-amino)-thiazol-4-one (Example 17) (90 mg, 0.15 mmol) in DMF (2 mL) was added potassium carbonate (43 mg, 0.31 mmol) followed by 2-Bromo-propionamide (29 mg, 0.19 mmol). The reaction mixture was stirred at room temperature for 4 hours and partitioned between water and ethyl acetate. The ethyl acetate layer was washed with brine, dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude solid. The crude solid was purified via flash chromatography (5% methanol in dichloromethane) to yield the title compound (60 mg, 60%).

Provenance & Evidence