Potassium Carbonate → HCID 67347521, compound

Participants

Reaction Steps

To a solution of 5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2-{[(3R,4S)-3-fluoropiperidin-4-yl](methyl)amino}-1,3-thiazol-4(5H)-one (previous Example 54) (90 mg, 0.16 mmol) in DMF (2 mL) was added potassium carbonate (45 mg, 0.32 mmol) followed by 2-Bromo-acetamide (27 mg, 0.20 mmol). The reaction mixture was stirred at room temperature for 4 hours and partitioned between water and ethyl acetate. The ethyl acetate layer was washed with brine, dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude solid. The crude solid was purified via flash chromatography (5% methanol in dichloromethane) to yield the title compound (63 mg, 64%).

Provenance & Evidence